On the booster-caused immune tolerance data & chronic covid
Synergy effects and new paths towards a Marek's situation
Gato and Igor Chudov just reported on this issue, which stems from a couple of recent studies thoroughly referenced by a Dutch blogger who calls himself Rintrah:
“Class switch towards non-inflammatory IgG isotypes after repeated SARS-CoV-2
mRNA vaccination”
These studies basically show that the vaccinations, especially the boosters, alter the immune profile of recipients such that covid infections get “tolerated” by the immune system.
There’s a substitution in the vaccinated of virus-neutralizing antibodies for non-inflammatory ones, a “class switch” from antibodies that work towards clearing the virus from our system, to a category of antibodies whose purpose is to desensitize us to irritants and allergens. So you don’t get an inflammatory response to your dog; so you can become “immune” to allergens.
This substitution is extensive, meaning that the particular subcategory of antibodies gets dominated by the non-inflammatory type.
The mechanism for this seems to be unknown, but the net effect is that the inflammatory response to covid infection gets down-regulated. This means that full-blown infections will present with milder symptoms, and that they won’t get cleared as effectively (partly since fever and inflammation are essential to your body getting rid of a pathogen).
If the data on the substitution holds up and is generalizable, it’s plausible that vaccinated individuals will tend towards a situation of long-term, repeat infections that do not get cleared, and promote systemic damage.
Combine this with the extensive data on OAS/the Hoskins effect, and we potentially get two separate avenues for immune suppression. I.e. the first one would be the Hoskins effect/antigenic original sin where immunity fixates on the narrow vaccination, the SP from the classic "Wuhan strain", and the second one would be in terms of this newly-observed IgG4 substitution.
Both of these separate avenues could then independently undermine the capability of the multiply vaccinated to clear not only covid infections but increasingly other viral infections which may opportunistically evolve to exploit this immunity gap created by substitution, potentially resulting in these "invisible", low-intensity infections which elicit a weak inflammatory response - yet which crowd the body with viruses and promote systemic damage.
This is very bad. It possibly means a billion people might get something akin to AIDS.
In light of what’s increasingly called an RSV crisis, and the persistent viral infections many of us see everywhere around, these findings are ominous. A close friend in otherwise perfect health has had a cold for more than a month. Severe relapses with debilitating fever. Vaccinated, of course.
But what additionally bothers me at this moment is that we also get separate causal mechanisms towards a Marek’s disease situation, i.e. a suppression of the selection processes that disfavour “hotter” strains.
We have a basic “leaky vaccine” situation that allows the host to survive yet pass on the more lethal strain that otherwise would have prevented widespread transmission, and on top of this, we get a selection mechanism which will favour strains that develop non-inflammatory characteristics exclusively in the vaccinated host, potentially allowing for a much greater replication as well as spread than otherwise.
In other words, this could add a layer of temporary protection from rapid lethality (e.g. through cytokine storms or intense inflammation) in the vaccinated (which nonetheless is damaging in the long-term), and which promotes both transmission as well as viral load. And this is not exclusively in relation to covid due to the indirect selection pressures connected to the character of the IgG4 substitution:
What I’m trying to say, is that there are now certain non-self amino acid chains that billions of human beings around the world are suddenly learning to tolerate. RNA respiratory viruses all work with pretty similar building blocks.
Some of these amino acid chains that we now tolerate in the case of SARS2, are chains that also show up in other respiratory viruses. And there will be respiratory viruses, that don’t have those chains yet, but can mutate themselves, to incorporate them in positions where they now currently have to deal with potent IgG3 antibodies.
(https://www.rintrah.nl/the-trainwreck-of-all-trainwrecks-billions-of-people-stuck-with-a-broken-immune-response/)
There’s a possible synergy here whose implications are going to keep me awake tonight.
I just read your comment on John Steppling's most recent post. Would you be willing to write more about depopulation and biopolitics and the rejection of the transcendent? That's something I've been wrestling with: The WEF crowd are monsters, but also my sense is that humanity must return to living within planetary limits.
Yes and here we have the perfect set up for a long,slow kill of a significant portion of the population.